A Case of Osmotic Demyelination Presenting with Severe Hypernatremia
Electrolytes & Blood Pressure
; : 30-36, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-16300
Biblioteca responsável:
WPRO
ABSTRACT
Osmotic demyelination syndrome is a demyelinating disorder associated with rapid correction of hyponatremia. But, it rarely occurs in acute hypernatremia, and it leads to permanent neurologic symptoms and is associated with high mortality. A 44-year-old woman treated with alternative medicine was admitted with a history of drowsy mental status. Severe hypernatremia (197mEq/L) with hyperosmolality (415mOsm/kgH2O) was evident initially and magnetic resonance imaging revealed a high signal intensity lesion in the pons, consistent with central pontine myelinolysis. She was treated with 0.45% saline and 5% dextrose water and intravenous corticosteroids. Serum sodium normalized and her clinical course gradually improved. Brain lesion of myelinolysis also improved in a follow-up imaging study. This is the first report of a successful treatment of hypernatremia caused by iatrogenic salt intake, and it confirms the importance of adequate fluid supplementation in severe hypernatremia.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Ingestão de Sal
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sódio
/
Encéfalo
/
Terapias Complementares
/
Ponte
/
Imageamento por Ressonância Magnética
/
Água
/
Seguimentos
/
Mortalidade
/
Doenças Desmielinizantes
/
Corticosteroides
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Electrolytes & Blood Pressure
Ano de publicação:
2015
Tipo de documento:
Artigo