Clinical Features of Drug-induced Liver Injury According to Etiology
Journal of Korean Medical Science
; : 1815-1820, 2015.
Article
em En
| WPRIM
| ID: wpr-164153
Biblioteca responsável:
WPRO
ABSTRACT
Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Aspartato Aminotransferases
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Estudos Retrospectivos
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Suplementos Nutricionais
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Preparações de Plantas
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Alanina Transaminase
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Medicamentos sob Prescrição
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Doença Hepática Induzida por Substâncias e Drogas
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República da Coreia
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Fitoterapia
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2015
Tipo de documento:
Article