Cell-based Immunotherapy for Colorectal Cancer with Cytokine-induced Killer Cells
Immune Network
; : 99-108, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-168218
Biblioteca responsável:
WPRO
ABSTRACT
Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%. Over the past decade, advances in combination chemotherapy regimens for colorectal cancer have led to significant improvement in progression-free and overall survival. However, patients with metastatic disease gain little clinical benefit from conventional therapy, which is associated with grade 3~4 toxicity with negative effects on quality of life. In previous clinical studies, cell-based immunotherapy using dendritic cell vaccines and sentinel lymph node T cell therapy showed promising therapeutic results for metastatic colorectal cancer. In our preclinical and previous clinical studies, cytokine-induced killer (CIK) cells treatment for colorectal cancer showed favorable responses without toxicities. Here, we review current treatment options for colorectal cancer and summarize available clinical studies utilizing cell-based immunotherapy. Based on these studies, we recommend the use CIK cell therapy as a promising therapeutic strategy for patients with metastatic colorectal cancer.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasias Colorretais
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Qualidade de Vida
/
Células Dendríticas
/
Vacinas
/
Neoplasias Colorretais
/
Incidência
/
Taxa de Sobrevida
/
Mortalidade
/
Quimioterapia Combinada
/
Células Matadoras Induzidas por Citocinas
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Aspecto:
Preferência do paciente
Limite:
Humanos
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2016
Tipo de documento:
Artigo