Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 2104-2108, 2001.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-169204
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
This study was performed to evaluate C to T substitution at nucleotide 677 of meth-ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies.METHODS:
Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis.RESULTS:
The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%).CONCLUSION:
It seems like that there is no evidence of association of preeclampsia with meth-ylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredutases
/
Pré-Eclâmpsia
/
Mapeamento por Restrição
/
Reação em Cadeia da Polimerase
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Alelos
/
Frequência do Gene
/
Genótipo
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2001
Tipo de documento:
Artigo