Sluggish decline in a post-transplant model for end-stage liver disease score is a predictor of mortality in living donor liver transplantation / 대한마취과학회지
Korean Journal of Anesthesiology
; : 160-166, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-170582
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The pre-transplant model for end-stage liver disease (pre-MELD) score is controversial regarding its ability to predict patient mortality after liver transplantation (LT). Prominent changes in physical conditions through the surgery may require a post-transplant indicator for better mortality prediction. We aimed to investigate whether the post-transplant MELD (post-MELD) score can be a predictor of 1-year mortality.METHODS:
Perioperative variables of 269 patients with living donor LT were retrospectively investigated on their association with 1-year mortality. Post-MELD scores until the 30th day and their respective declines from the 1st day post-MELD score were included along with pre-MELD, acute physiology and chronic health evaluation (APACHE) II, and sequential organ failure assessment (SOFA) scores on the 1st post-transplant day. The predictive model of mortality was established by multivariate Cox's proportional hazards regression.RESULTS:
The 1-year mortality rate was 17% (n = 44), and the leading cause of death was graft failure. Among prognostic indicators, only post-MELD scores after the 5th day and declines in post-MELD scores until the 5th and 30th day were associated with mortality in univariate analyses (P or =24 hours were the earliest independent predictors of 1-year mortality.CONCLUSIONS:
A sluggish decline in post-MELD scores during the early post-transplant period may be a meaningful prognostic indicator of 1-year mortality after LT.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Objetivo 10: Doenças transmissíveis
/
Doenças do Sistema Digestório
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Respiração Artificial
/
Análise Multivariada
/
Estudos Retrospectivos
/
Causas de Morte
/
Transplante de Fígado
/
APACHE
/
Doadores Vivos
/
Transplantes
/
Fígado
/
Hepatopatias
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Aspecto:
Preferência do paciente
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2010
Tipo de documento:
Artigo