Metronidazole-induced encephalopathy in a patient with liver cirrhosis / 대한간학회지
The Korean Journal of Hepatology
; : 157-160, 2011.
Article
em En
| WPRIM
| ID: wpr-172637
Biblioteca responsável:
WPRO
ABSTRACT
Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes. Encephalopathy associated with metronidazole administration occurs rarely and depends on the cumulative metronidazole dose, and most patients with this condition recover rapidly after discontinuation of therapy. Because metronidazole is metabolized in the liver and can be transported by the cerebrospinal fluid and cross the blood-brain barrier, it may induce encephalopathy even at a low cumulative dose in patients with hepatic dysfunction. We experienced a patient who showed ataxic gait and dysarthric speech after receiving metronidazole for the treatment of hepatic encephalopathy that was not controlled by the administration of lactulose. The patient was diagnosed as metronidazole-induced encephalopathy, and stopping drug administration resulted in a complete recovery from encephalopathy. This case shows that caution should be exercised when administering metronidazole because even a low dose can induce encephalopathy in patients with liver cirrhosis.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Encefalopatias
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Imageamento por Ressonância Magnética
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Tomografia Computadorizada por Raios X
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Encefalopatia Hepática
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Cirrose Hepática
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Metronidazol
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Anti-Infecciosos
Limite:
Humans
/
Male
Idioma:
En
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2011
Tipo de documento:
Article