Roles of intestinal epithelial cells in the maintenance of gut homeostasis
Experimental & Molecular Medicine
; : e338-2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-17716
Biblioteca responsável:
WPRO
ABSTRACT
The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the host by constructing mucosal barriers, secreting various immunological mediators and delivering bacterial antigens. Mucosal barriers, including physical barriers and chemical barriers, spatially segregate gut microbiota and the host immune system to avoid unnecessary immune responses to gut microbes, leading to the intestinal inflammation. In addition, various immunological mediators, including cytokines and chemokines, secreted from intestinal epithelial cells stimulated by gut microbiota modulate host immune responses, maintaining a well-balanced relationship between gut microbes and the host immune system. Therefore, impairment of the innate immune functions of intestinal epithelial cells is associated with intestinal inflammation.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Zoonoses
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acessibilidade Arquitetônica
/
Citocinas
/
Quimiocinas
/
Células Epiteliais
/
Microbioma Gastrointestinal
/
Homeostase
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Sistema Imunitário
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Inflamação
/
Intestinos
/
Antígenos de Bactérias
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo