Pharmacogenomics of Antidepressants / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 75-84, 2002.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-180089
Biblioteca responsável:
WPRO
ABSTRACT
In an approach known as pharmacogenomics, many psychopharmacologists hope to match depressive patients to specific drugs based on the patients' genetic profiles. Many researchers and pharmaceutical companies are investing their efforts and vast amount of money in the pharmacogenomic aspects of many diseases. The numbers of pharmacogenomic reports are relatively small in the field of antidepressants because, in part, depressive disorders are multifactorial diseases with diversity of pathophysiology. In this review, the usefulness of therapeutic drug monitoring, phenotyping and genotyping of drug metabolizing enzymes before administration of antidepressants to depressive patients was discussed. Pharmacodynamic aspects of antidepressants, focused on the results of former studies about the relationship of the polymorphisms of the several genes (serotonin transporter genes, serotonin receptors, etc) and drug response, were also discussed.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacogenética
/
Receptores de Serotonina
/
Monitoramento de Medicamentos
/
Depressão
/
Transtorno Depressivo
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
/
Esperança
/
Antidepressivos
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2002
Tipo de documento:
Artigo