Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease
Experimental & Molecular Medicine
; : 494-501, 2006.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-181050
Biblioteca responsável:
WPRO
ABSTRACT
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells and break B-cell tolerance to self-Ags in the recipient mouse. The functional recovery of donor CD8+T cells can result in the conversion of cGVHD to acute GVHD (aGVHD), indicating that donor CD8+T-cell anergy is a restriction factor in the development of cGVHD. In this report, we present evidence that donor CD4+CD25+regulatory T cells (T(reg) cells) are critical in maintaining the donor CD8+T-cell anergy and thus suppressing the development of aGVHD in mice that are naturally prone to cGVHD. Our results provide a novel insight into the role of T(reg) cells in determining cGVHD versus aGVHD.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos T CD4-Positivos
/
Doença Crônica
/
Linfócitos T Reguladores
/
Anergia Clonal
/
Linfócitos T CD8-Positivos
/
Subunidade alfa de Receptor de Interleucina-2
/
Doença Enxerto-Hospedeiro
/
Tolerância Imunológica
/
Camundongos Endogâmicos DBA
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo