A Clinical Study of chronic Cutaneous GVHD / 대한피부과학회지
Korean Journal of Dermatology
; : 93-101, 1996.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-181153
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
With progressive improvement in the fraction of long-term surviviors, chronic GVHD has emerged as a increasingly frequent complication of allogenic bone marrow transplantation. Except for a few case reports, there has been no clinical study of chronic cutaneous GVHD in Korea so far.OBJECTIVE:
In the present study we planned to investigate the clinical characteristics of chronic cutaneous GVHD and to compare the clinical manifestation and incidence of chronic cutaneous GVHD in Korea with previous reports in U.S.A. and Europe.METHODS:
On the basis of the patients' charts and the records of bone marrow transplantation, we investigated the incidence of chronic cutaneous GVHD in Korean leukemia patients and studied the clinical manifestations of chronic cutaneous GVHD ocurring in 16 patients whose diagnosis was confirmed by histopathologic findings of skin biopsy. We also analysed whether total body irrdiation before bone marrow transplantation, GVHD prophylaxis and presence of preceding acute GVHD affected chronic cutaneous GVHD.RESULTS:
1. The incidence in chronic cutaneous GVHD in Korea was lower than that in Caucasian countries. 2. The onset was milder than that in Caucasians. 3. The clinical manifestation was earlier than that in Caucasians. 4. The relationship between the GVHD prophylaxis and incidence chronic cutaneous GVHD was not significant. 5. The incidence of chronic cutaneous GVHD in the presence of preceding acute GVHD was higher than in cases with no preceding acute GVHD.CONCLUSION:
We speculate that the low incidence of chronic cutaneous GVHD and clinical characteristics differing from the reports in the U.S.A. and Europe might be unassociated with irradiation, GVHD prophylaxis or the presence of preceding acute GVHD but maybe related to differences in genetic background.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Biópsia
/
Leucemia
/
Incidência
/
Transplante de Medula Óssea
/
Diagnóstico
/
Europa (Continente)
/
Coreia (Geográfico)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
/
Europa
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1996
Tipo de documento:
Artigo