Interaction of Vitamin D and Smoking on Inflammatory Markers in the Urban Elderly / 예방의학회지
Journal of Preventive Medicine and Public Health
; : 249-256, 2015.
Article
em En
| WPRIM
| ID: wpr-182017
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly. METHODS: We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans > or =60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times. RESULTS: The association of vitamin D and hs-CRP was significant after adjusting for known confounders (beta=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: beta=-0.375, p=0.013; non-smokers: beta=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: beta=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (beta=0.003, p=0.805). CONCLUSIONS: Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association. Vitamin D deficiency was not significantly associated with WBC count.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
População Urbana
/
Vitamina D
/
Deficiência de Vitamina D
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Proteína C-Reativa
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Biomarcadores
/
Fumar
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Índice de Massa Corporal
/
25-Hidroxivitamina D 2
/
Inflamação
/
Contagem de Leucócitos
Tipo de estudo:
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Journal of Preventive Medicine and Public Health
Ano de publicação:
2015
Tipo de documento:
Article