Association between Dopamine D4 Receptor Gene Polymorphism and Scores on a Continuous Performance Test in Korean Children with Attention Deficit Hyperactivity Disorder
Psychiatry Investigation
; : 216-221, 2009.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-183813
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the association between a variable number of tandem repeats polymorphism at the dopamine D4 receptor gene (DRD4) and the performance of children with attention deficit hyperactivity disorder (ADHD) in a continuous performance test (CPT).METHODS:
This study included 72 ADHD children (mean age=9.39+/-2.05 years) who were recruited from one child psychiatric clinic. The omission errors, commission errors, reaction time and reaction standardization in the CPT were computed. The number of 48-base pairs tandem repeats in the exon III of DRD4 was analyzed in a blind manner.RESULTS:
The homozygosity of the 4-repeat allele at DRD4 was significantly associated with fewer commission errors (t=2.364, df=28.685, p=0.025) and standard deviation of reaction time (t=2.351, df=24.648, p=0.027) even after adjusting for age. The results of analyses of CPT measured values among three groups showed that the group with higher frequency of the 4-repeat allele showed a lower mean score of commission errors (F=4.268, df=2, p=0.018).CONCLUSION:
These results suggest a protective role of 4-repeat allele of the DRD4 polymorphisms on commission errors in the CPT in children with ADHD.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Reação
/
Transtorno do Deficit de Atenção com Hiperatividade
/
Dopamina
/
Éxons
/
Repetições Minissatélites
/
Sequências de Repetição em Tandem
/
Alelos
/
Receptores de Dopamina D4
Tipo de estudo:
Ensaio clínico controlado
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2009
Tipo de documento:
Artigo