The Expression of High Mobility Group I (Y) Proteins in Human Breast Cancer
Journal of the Korean Surgical Society
; : 136-140, 2001.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-186643
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The precise mechanisms of tumorigenesis of breast cancer remains unknown in spite of major efforts. Recent studies have shown that High Mobility Group I (Y) Proteins [HMGI(Y)] have an important role in the regulation of chromatin structure and function, and that HMGI(Y) protein expression is generally correlated with a malignant phenotype. This study was undertaken to define the relationship of the HMGI(Y) protein expression between malignant breast tissue and non-malignant breast tissue in human, and clinico- pathologic findings were reviewed for this purpose.METHODS:
Using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for HMGI(Y) with beta-actin, this study demonstrated the expression of HMGI(Y). The p53, ER, and PR. were defined by immunohistochemical staining.RESULTS:
The HMGI(Y) expression was increased in the malignant tissue (90%), than in benign (76.9%) or normal (65%) tissue (p=0.031). As for the invasive ductal cancers, there was no difference between the HMGI(Y) expression and histopathologic parameters.CONCLUSION:
These results suggest that the HMGI(Y) expression may be of little pathogenetic prognostic importance in human breast cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Mama
/
Neoplasias da Mama
/
Cromatina
/
Actinas
/
Carcinogênese
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2001
Tipo de documento:
Artigo