A Case of Transient Neonatal Pustular Melanosis

ABSTRACT

Transient neonatal pustular melanosis(TNPM) is a benign, self-limited, cutaneous disorder of unknown etiology. Significant physical findings are limited to the skin. Hematologic and serological tests are normal. Cultures of blood and pustule are negative. Biopsy specimens from pustules show a intracorneal or subcorneal separation containing neutrophils and also some eosinophils. TNPM produces only cutaneous lesions and requires no treatment. So it is essential to differentiate TNPM and other neonatal skin lesions. We experienced a case of TNPM in a male newborn with generalized superficial vesicopustules which developed into pigmented macules and report this case with review of related literatures.