A Case of Resistance to Thyroid Hormone with Thyroid Cancer
Journal of Korean Medical Science
; : 1368-1371, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-187903
Biblioteca responsável:
WPRO
ABSTRACT
Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TRbeta) gene. We recently treated a 38-yr-old woman with RTH who had incidental papillary thyroid carcinoma. She presented with goiter and displayed elevated thyroid hormone levels with an unsuppressed TSH. She was determined to harbor a missense mutation of M310T in exon 9 of the TRbeta gene, and diagnosed with generalized RTH. This mutation has not yet been reported in Korea. RTH is very rare and easily overlooked, but should be considered in patients who present with goiter and elevated thyroid hormone levels with an unsuppressed TSH. The association between thyroid cancer and RTH needs further study.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glândula Tireoide
/
Hormônios Tireóideos
/
Neoplasias da Glândula Tireoide
/
Éxons
/
Síndrome da Resistência aos Hormônios Tireóideos
/
Mutação de Sentido Incorreto
/
Receptores beta dos Hormônios Tireóideos
/
Diagnóstico Diferencial
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2010
Tipo de documento:
Artigo