Immune Disorders and Its Correlation with Gut Microbiome
Immune Network
; : 129-138, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-192567
Biblioteca responsável:
WPRO
ABSTRACT
Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies support the association of hygiene hypothesis in allergic immune disorders that a lack of early childhood exposure to diverse microorganism increases susceptibility to allergic diseases. Among the symbiotic microorganisms (e.g. gut flora or probiotics), probiotics confer health benefits through multiple action mechanisms including modification of immune response in gut associated lymphoid tissue (GALT). Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse immune disorders, this effect is strain specific and needs to apply specific probiotics for specific allergic diseases. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Entorses e Distensões
/
Países Desenvolvidos
/
Probióticos
/
Dermatite Atópica
/
Metagenoma
/
Hipótese da Higiene
/
Doenças do Sistema Imunitário
/
Benefícios do Seguro
/
Tecido Linfoide
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2012
Tipo de documento:
Artigo