Animal Models for Orofacial Neuropathic Pain / 한양의대학술지
Hanyang Medical Reviews
; : 107-115, 2011.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-19503
Biblioteca responsável:
WPRO
ABSTRACT
Orofacial neuropathic pain is initiated by extraction of teeth or nerve injury from trauma in the trigeminal nerve that innervates the facial area. In the experiment, orofacial neuropathic pain usually occurred following injury of peripheral trigeminal nerve including infra-orbital nerve, inferior alveolar nerve, or mental nerve. In addition, pathology from trigeminal nerve root or ganglion is involved in orofacial neuropathic pain. This study introduced various animal models that help us study the underlying mechanisms of development or maintenance of orofacial neuropathic pain. One of the most typical symptoms of orofacial neuropathic pain is hypersensitivity to the innocuous mechanical stimuli. Our study presents a novel method to evaluate mechanical allodynia in rats with orofacial neuropathic pain. Recently, accumulate evidence support participation of central glial cells in the development or maintenance of orofacial neuropathic pain. Signaling molecules in glial cells also play an important role in neuropathic pain in the orofacial area.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dente
/
Nervo Trigêmeo
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Neuralgia do Trigêmeo
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Dor Facial
/
Neuroglia
/
Modelos Animais
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Cistos Glanglionares
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Hiperalgesia
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Hipersensibilidade
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Nervo Mandibular
Limite:
Animais
Idioma:
Coreano
Revista:
Hanyang Medical Reviews
Ano de publicação:
2011
Tipo de documento:
Artigo