Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways
Journal of Bacteriology and Virology
; : 288-294, 2016.
Article
em En
| WPRIM
| ID: wpr-195571
Biblioteca responsável:
WPRO
ABSTRACT
Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the antiinflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor (TNF)-α. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of IκBα. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fosforilação
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Hominidae
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Interleucinas
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Óxido Nítrico Sintase Tipo II
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Macrófagos
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Óxido Nítrico
Limite:
Humans
Idioma:
En
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2016
Tipo de documento:
Article