The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Immune Network
; : 291-295, 2012.
Article
em En
| WPRIM
| ID: wpr-20062
Biblioteca responsável:
WPRO
ABSTRACT
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-alpha. The fraction also increased the production of TGF-beta and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-alpha, as well as secretion of VEGF, TGF-beta and HS may have a new bioactive material for the treatment of skin wound.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sêmen
/
Pele
/
Úlcera
/
Cicatrização
/
Citocinas
/
Fator de Crescimento Transformador beta
/
Fator de Necrose Tumoral alfa
/
Pé Diabético
/
Fator A de Crescimento do Endotélio Vascular
/
Ácidos Graxos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2012
Tipo de documento:
Article