Valproic Acid Regulates alpha-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes
Biomolecules & Therapeutics
; : 222-228, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-202360
Biblioteca responsável:
WPRO
ABSTRACT
Although the role of alpha-synuclein aggregation on Parkinson's disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of alpha-synuclein are unclear yet. We recently reported that alpha-synuclein is expressed and secreted from cultured astrocytes. In this study, we investigated the effect of valproic acid (VPA), which has been suggested to provide neuroprotection by increasing alpha-synuclein in neuron, on alpha-synuclein expression in rat primary astrocytes. VPA concentration-dependently increased the protein expression level of alpha-synuclein in cultured rat primary astrocytes with concomitant increase in mRNA expression level. Likewise, the level of secreted alpha-synuclein was also increased by VPA. VPA increased the phosphorylation of Erk1/2 and JNK and pretreatment of a JNK inhibitor SP600125 prevented the VPA-induced increase in alpha-synuclein. Whether the increased alpha-synuclein in astrocytes is involved in the reported neuroprotective effects of VPA awaits further investigation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Fosforilação
/
Acetilação
/
RNA Mensageiro
/
Astrócitos
/
Ácido Valproico
/
Fármacos Neuroprotetores
/
Sistema de Sinalização das MAP Quinases
/
Alfa-Sinucleína
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2013
Tipo de documento:
Artigo