Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain
Clinical and Experimental Vaccine Research
; : 114-118, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-203143
Biblioteca responsável:
WPRO
ABSTRACT
We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 10: Doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Suínos
/
Virulência
/
Cabras
/
Células Clonais
/
Clonagem Molecular
/
DNA Complementar
/
Vírus da Febre Aftosa
/
Anticorpos Neutralizantes
/
Febre Aftosa
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Clinical and Experimental Vaccine Research
Ano de publicação:
2015
Tipo de documento:
Artigo