Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection
Gut and Liver
; : 340-345, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-203893
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication.METHODS:
This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE).RESULTS:
In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups.CONCLUSIONS:
According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (ClinicalTrial.gov NCT01645761).
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 10: Doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquema de Medicação
/
Pronase
/
Método Simples-Cego
/
Estudos Prospectivos
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Resultado do Tratamento
/
Claritromicina
/
Quimioterapia Combinada
/
Inibidores da Bomba de Prótons
Tipo de estudo:
Ensaio clínico controlado
/
Guia de prática clínica
/
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Gut and Liver
Ano de publicação:
2015
Tipo de documento:
Artigo