Dehydroepiandrosterone Sulfate Level Varies Nonlinearly with Symptom Severity in Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
; : 163-169, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-203965
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients.METHODS:
We recruited 117 subjects from a general practice. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). Depressive symptoms were divided into three subdomains according to BDI items; somatic symptoms, guilt and failure, and mood and inhibition.RESULTS:
In subjects with very-mild-to-moderate depression, the DHEA-s level increased as BDI score did. However, the DHEA-s levels in the subjects with severe depression were significantly lower than in subjects with moderate depression (p=0.003). DHEA-s level was correlated with the BDI subscore for guilt and failure in very-mild-to-moderate depression (r=0.365, p=0.006).CONCLUSION:
The DHEA-s level appears to be indicative of MDD severity with respect to depressive symptoms, especially regarding guilt and failure. Our findings suggest that the upregulation of DHEA-s may be a part of a compensatory process in very-mild-to-moderate depression, and the failure of this compensation mechanism may underlie the development of severe depression.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Características da População
/
Neuroendocrinologia
/
Biomarcadores
/
Regulação para Cima
/
Desidroepiandrosterona
/
Sulfato de Desidroepiandrosterona
/
Compensação e Reparação
/
Depressão
/
Transtorno Depressivo Maior
/
Diagnóstico Diferencial
Tipo de estudo:
Estudo diagnóstico
Aspecto:
Determinantes sociais da saúde
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2017
Tipo de documento:
Artigo