Role of Radiotherapy for Squamous Cell Carcinoma of the External Auditory Canal and Middle Ear / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
; : 173-180, 2009.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-21057
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To investigate the role of radiotherapy for squamous cell carcinomas of the external auditory canal and middle ear. MATERIALS ANDMETHODS:
A series of 35 patients who were treated at a single institution from 1981 through 2007 were retrospectively analyzed. Thirteen patients were treated by radiotherapy alone; four by surgery only and 18 by a combination of surgery and radiotherapy. The total radiation dose ranged from 39~70 Gy (median, 66 Gy) in 13~35 fractions for radiotherapy alone and 44~70 Gy (median, 61.2 Gy) in 22~37 fractions for the combined therapy. Clinical end-points were the cause of specific survival (CSS) and local relapse-free survival (LRFS). The median follow-up time was 2.8 years (range, 0.2~14.6 years).RESULTS:
The 3-year CSS and LRFS rate was 80% and 63%, respectively. Based on a univariate analysis, performance status and residual disease after treatment had a significant impact on CSS; performance status and histologic grade for LRFS. Patients treated by radiotherapy alone had more residual disease following the course of treatment compared to patients treated with the combined therapy; 69% vs. 28%, respectively.CONCLUSION:
Our results suggest that radiation alone was not an inferior treatment modality for CSS compared to the combined therapy for squamous cell carcinoma of the external auditory canal and middle ear. However, local failure after radiotherapy is the main issue that will require further improvement to gain optimal local control.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Carcinoma de Células Escamosas
/
Estudos Retrospectivos
/
Seguimentos
/
Meato Acústico Externo
/
Orelha Média
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Ano de publicação:
2009
Tipo de documento:
Artigo