Role of placenta growth factor in cancer and inflammation
Experimental & Molecular Medicine
; : 10-19, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-211723
Biblioteca responsável:
WPRO
ABSTRACT
Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the VEGF family and is upregulated mainly in pathologic conditions. Recently, PlGF was discovered having a proinflammatory role in inflammatory arthritis and its serum level drew attention not only as a useful surrogate biomarker but also a potential therapeutic target in atherosclerosis and various cancers. Particularly, PlGF has attractive clinical values because endogenous PlGF is redundant for vascular development and physiological vessel maintenance in healthy adults. However, there have been conflicting results about the efficacy of PlGF inhibition depending on the experimental and clinical settings. Further close investigations for resolving the puzzle of PlGF biology are required.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas da Gravidez
/
Artrite Reumatoide
/
Biomarcadores
/
Transdução de Sinais
/
Aterosclerose
/
Inflamação
/
Neoplasias
/
Neovascularização Patológica
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo