Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients
Journal of Korean Medical Science
; : 782-787, 2014.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-212026
Biblioteca responsável:
WPRO
ABSTRACT
Clustered occurrences of ankylosing spondylitis (AS) in family have been noticed. We evaluated patients with AS confirmed by the modified New York criteria for familial history of AS (one or more first to third degree relatives). The clinical characteristics and the recurrence risks (number of AS patients/number of familial members) of the familial AS compared to sporadic AS were investigated. Out of a total of 204 AS patients, 38 patients (18.6%) reported that they had a familial history of AS. The recurrence risks in the familial AS patients for first, second and third degree family members were 14.5%, 5.2%, and 4.4% respectively. Erythrocyte sedimentation rate (ESR) (22.6+/-22.2 vs 35.4+/-34.4, P=0.029) and C-reactive protein (CRP) (1.24+/-1.7 vs 2.43+/-3.3, P=0.003) at diagnosis, body mass index (21.9+/-2.7 vs 23.7+/-3.3, P=0.002) and frequency of oligoarthritis (13.2% vs 33.7%, P=0.021) were significantly lower in the familial form. The presence of HLA-B27 (97.4% vs 83.1%, P=0.044) was significantly higher in familial AS. In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Artrite Juvenil
/
Recidiva
/
Espondilite Anquilosante
/
Índice de Gravidade de Doença
/
Sedimentação Sanguínea
/
Proteína C-Reativa
/
Família
/
Índice de Massa Corporal
/
Antígeno HLA-B27
Tipo de estudo:
Estudo de etiologia
/
Pesquisa qualitativa
/
Fatores de risco
Aspecto:
Determinantes sociais da saúde
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2014
Tipo de documento:
Artigo