Inhibition of glutathione metabolism attenuates esophageal cancer progression
Experimental & Molecular Medicine
; : e318-2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-212090
Biblioteca responsável:
WPRO
ABSTRACT
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with regard to mortality and prognosis, and the 5-year survival rate for all patients diagnosed with ESCC remains poor. A better understanding of the biological mechanisms of ESCC tumorigenesis and progression is of great importance to improve treatment of this disease. In this study, we demonstrated that the glutathione metabolism pathway is highly enriched in ESCC cells compared with normal esophageal epithelial cells in an in vivo mouse model. In addition, treatment with L-buthionine-sulfoximine (BSO) to deplete glutathione decreased the ESCC tumor burden in mice, thus demonstrating the critical role of glutathione metabolism in ESCC progression. BSO treatment also led to decreased cell proliferation and activation of cell apoptosis in ESCC. Finally, BSO treatment blocked NF-κB pathway activation in ESCC. Our study reveals a new pathway that regulates ESCC progression and suggests that inhibition of glutathione metabolism may be a potential strategy for ESCC treatment.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Digestório
/
Doenças do Sistema Endócrino
/
Neoplasia Esofágica
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Taxa de Sobrevida
/
Mortalidade
/
Apoptose
/
Carga Tumoral
/
Proliferação de Células
/
Células Epiteliais
/
Carcinogênese
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo