Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 2124-2129, 2002.
Article
em Ko
| WPRIM
| ID: wpr-213717
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
DNA
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Imuno-Histoquímica
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Carcinoma de Células Escamosas
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Colo do Útero
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DNA Topoisomerases Tipo I
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Receptor ErbB-2
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2002
Tipo de documento:
Article