Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
The World Journal of Men's Health
; : 43-50, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-214130
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS ANDMETHODS:
Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.RESULTS:
Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.CONCLUSIONS:
Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Superóxido Dismutase
/
Testículo
/
Testosterona
/
Fibrose
/
Ratos Sprague-Dawley
/
Guanosina Monofosfato
/
Estresse Oxidativo
/
Óxido Nítrico Sintase
/
Modelos Animais
/
Pressão Arterial
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The World Journal of Men's Health
Ano de publicação:
2017
Tipo de documento:
Artigo