An orthotopic nude mouse model of tongue carcinoma
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 490-495, 2011.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-217787
Biblioteca responsável:
WPRO
ABSTRACT
INTRODUCTION:
Development of carcinoma on oral tongue may cause bilateral cervical lymph node metastasis, rapid invasion and growth of the cancer cells due to rich blood supply in muscle tissues. It is not only difficult to develop an animal experimental model, but also to proceed follow-up research after the development of such model as the induction of cancer lead to difficulty in taking nutrition for the experimental animals that often causes early death. MATERIALS ANDMETHODS:
IIn this study, author have transplanted YD-10Bmod cells into nude mouse oral tongues with different cells number (5x10(4), 5x10(5), 5x10(6) cells/mouse) and observed the development aspect of oral tongue cancers.RESULTS:
The cancer developed from orthotopic transplantation of YD-10Bmod cells into nude mouse oral tongue show invasion and central necrosis of the tumor, similar to the cancers developed human oral tongue cancer. The difference in tumor size and the time of central necrosis development depending on the number of transplanted tumor cells shows the feasibility of extending the survival period of the nude mouse by limiting the transplanted tumor cells to <5x10(4) cells/mouse or under per nude mouse.CONCLUSION:
This nude mouse model could be used effectively in developing effective chemotheray agent and establishing an animal experimental model that can be used to study the mechanism of cervical lymph node metastasis of the oral tongue cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Língua
/
Neoplasias da Língua
/
Carcinoma de Células Escamosas
/
Linhagem Celular
/
Transplantes
/
Experimentação Animal
/
Linfonodos
/
Camundongos Nus
/
Músculos
/
Necrose
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2011
Tipo de documento:
Artigo