Clinical Course of Patients with IgA Nephropathy between Combined Treatment of Immunosuppressive Agents and ACE Inhibitor and ACE Inhibitor alone
The Korean Journal of Internal Medicine
; : 105-109, 2001.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-219316
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
It has not been clear whether immunosuppressive therapy favorably influences renal function and proteinuria in IgA nephropathy (IgAN). Angiotensin converting enzyme inhibitor (ACEi) has an anti-proteinuric effect in IgAN. A retrospective study was done to see whether the addition of immunosuppressive therapy to ACEi produces a more excellent anti-proteinuric effect and preserves better renal function than ACEi alone.METHODS:
A total of 49 patients with proteinuria>1.0 g/day and serum creatinine concentrations<1.5 mg/dL were followed-up from at least 1 year to 9 years. Among them, 25 patients were treated with the combination of cyclophosphamide, prednisolone and ACEi while the other 24 were treated with ACEi alone.RESULTS:
The combination therapy or ACEi alone both reduced proteinuria with significant value (the combination group from 5.74+/-5.08 to 2.29+/-2.77 g/day, ACEi group from 3.85+/-2.54 to 1.68+/-1.91 g/day), while no significant differences in reduction of proteinuria were noticed between the two groups. There was no significant elevation of serum creatinine in both groups during follow-up (the combination group from 0.91+/-0.20 to 1.03+/-0.38 mg/dL, ACEi group from 0.93+/-0.27 to 0.99+/-0.37 mg/dL). This study showed no significant differences in the change in slope of 1/serum creatinine levels during the follow-up period between the two groups.CONCLUSION:
We conclude that immunosuppressive therapy may not be beneficial in patients with proteinuric IgAN. ACEi may be a valuable therapeutic agent avoiding serious side effects of immunosuppressive agents.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Índice de Gravidade de Doença
/
Prednisolona
/
Estudo Comparativo
/
Inibidores da Enzima Conversora de Angiotensina
/
Probabilidade
/
Estudos Retrospectivos
/
Seguimentos
/
Resultado do Tratamento
/
Estatísticas não Paramétricas
/
Ciclofosfamida
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2001
Tipo de documento:
Artigo