A Successfully Treated Case of Recurrent Focal Segmental Glomerulosclerosis (FSGS) with Plasmapheresis and High dose Methylprednisolone Pulse Therapy
Childhood Kidney Diseases
; : 165-168, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-220621
Biblioteca responsável:
WPRO
ABSTRACT
Focal segmental glomerulosclerosis (FSGS) in children, which is a kind of nephrotic syndrome showing steroid resistance, usually progresses to a substantial number of end stage renal disease (ESRD). Although the pathogenesis of primary FSGS is unclear, several recent studies have reported that FSGS is associated with circulating immune factors such as soluble urokinase-type plasminogen activator receptor (suPAR) or anti-CD40 autoantibody. We report a successfully treated case of a 19-year-old female patient who experienced a recurrence of primary FSGS. After the diagnosis of FSGS, the patient progressed to ESRD and received a kidney transplantation (KT). Three days later, recurrence was suspected through proteinuria and hypoalbuminemia. She has been performed plasmapheresis and high dose methylprednisolone pulse therapy and shown remission status without increasing proteinuria for four years after KT. In conclusion, strong immunosuppressive therapy may be helpful for a good prognosis of recurrent FSGS, suppressing several immunologic circulating factors related disease pathogenesis.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
/
Doença Renal Crônica
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Proteinúria
/
Recidiva
/
Metilprednisolona
/
Glomerulosclerose Segmentar e Focal
/
Ativador de Plasminogênio Tipo Uroquinase
/
Transplante de Rim
/
Plasmaferese
/
Hipoalbuminemia
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Criança
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Childhood Kidney Diseases
Ano de publicação:
2017
Tipo de documento:
Artigo