Comparison of the Cobalt Alloy and Stainless Steel Core(r) Stent in a Porcine Coronary Restenosis Model
Korean Circulation Journal
; : 507-512, 2005.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-220835
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
The stent material and thickness may influence the rate of restenosis following coronary artery stenting. A thin strut cobalt-alloy stent has been developed in an attempt to reduce the restenosis rate, while maintaining the radiopacity and radial strength. The purpose of this study was to compare a stainless steel Core(r) stent (thickness 90 micrometer/HUMED Co. Ltd, Korea) with that of a cobalt alloy Core(r) stent (thickness 60 micrometer/HUMED Co. Ltd, Korea) in a porcine coronary stent restenosis model. MATERIALS ANDMETHODS:
The cobalt alloy (Co-alloy) and stainless steel (SS) stents were implanted in 24 porcine coronary arteries. Four weeks after stenting, the pigs were sacrificed after quantitative coronary angiography (QCA). The coronary arteries were perfusion-fixed and stained, and a pathological examination performed by computer-aided histomorphometry.RESULTS:
The minimal luminal diameter at 4 weeks was larger in the Co-alloy than the SS group according to the QCA (1.8+/-0.8 mm vs. 2.7+/-0.8 mm, p=0.019). The neointimal area was significantly smaller in the Co-alloy than the SS group (1.96+/-0.68 mm2 vs. 0.89+/-0.27 mm2, p<0.001). The intima/media area ratio was significant lower in the Co-alloy than the SS group (1.33+/-0.46 vs. 0.69+/-0.21, p=0.003).CONCLUSION:
The thin strut cobalt alloy Core(r) stent significantly reduces the neointimal formation compared to the stainless steel Core(r) stent in a porcine coronary stent injury model.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenobarbital
/
Aço Inoxidável
/
Suínos
/
Stents
/
Angiografia Coronária
/
Cobalto
/
Vasos Coronários
/
Modelos Animais
/
Reestenose Coronária
/
Ligas
Idioma:
Coreano
Revista:
Korean Circulation Journal
Ano de publicação:
2005
Tipo de documento:
Artigo