Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
Diabetes & Metabolism Journal
; : 10-19, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-222887
Biblioteca responsável:
WPRO
ABSTRACT
Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have emerged as potential treatments for insulin resistance. The mechanistic basis for these antidiabetic effects has primarily been attributed to multiple metabolic and inflammatory functions. Here we review recent advances in our understanding of the association of ER stress with insulin resistance and the role of nuclear receptors in promoting ER stress resolution and improving insulin resistance in the liver.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Resistência à Insulina
/
Receptores Citoplasmáticos e Nucleares
/
Diabetes Mellitus Tipo 2
/
Retículo Endoplasmático
/
Resposta a Proteínas não Dobradas
/
Estresse do Retículo Endoplasmático
/
Insulina
/
Fígado
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2017
Tipo de documento:
Artigo