Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
Immune Network
; : 1-4, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-225186
Biblioteca responsável:
WPRO
ABSTRACT
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4+ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Linfócitos
/
Linfócitos T
/
Citocinas
/
Interleucina-4
/
Interleucina-5
/
Células Th2
/
Interleucina-13
/
Interleucina-17
/
Eosinófilos
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2010
Tipo de documento:
Artigo