Cut-Off Value and Factors Associated with a False Positive D-Dimer Result for Venous Thromboembolism in Koreans / 대한내과학회지
Korean Journal of Medicine
; : 372-378, 2013.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-225752
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The D-dimer value is a simple blood test used to evaluate venous thromboembolism (VTE). However, due to its low specificity, another test is needed for a definite diagnosis, such as a radiographic test. We evaluate the factors associated with a false positive D-dimer test and propose a new cut-off value for detecting VTE more effectively in Koreans.METHODS:
This was a retrospective, observational study. From January 2009 to December 2009, 2,047 patients (988 men, 63 +/- 15 years) had the D-dimer value checked to evaluate VTE. The main outcome of interest was a positive D-dimer test. Odds ratio and 95% confidence intervals were determined using logistic regression analysis. The new D-dimer cut-off was evaluated using receiver operating characteristics (ROC) curves.RESULTS:
The result was positive in 1,093 patients (53%), for a false positive percentage for VTE of 95% and a false negative percentage for VTE of 1%. Significant false positive predictors for a positive D-dimer were increasing age, trauma, postoperative, acute infection, tuberculosis, stroke, malignancy, chronic renal failure, acute coronary syndrome, heart failure, and lung disease. The discriminative value of the D-dimer test was assessed using ROC curve analysis. A D-dimer value of 0.68 mg/L on admission was the best cut-off value for predicting the development of VTE with a sensitivity of 95% and specificity of 57%.CONCLUSIONS:
Many factors affect the D-dimer value and we must consider these factors before using the D-dimer value to evaluate VTE. A D-dimer value of 0.68 mg/L appears to be a good cut-off value for evaluating VTE more effectively in Koreans.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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Doenças Negligenciadas
/
Tuberculose
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tuberculose
/
Produtos de Degradação da Fibrina e do Fibrinogênio
/
Modelos Logísticos
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Razão de Chances
/
Estudos Retrospectivos
/
Curva ROC
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Sensibilidade e Especificidade
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Acidente Vascular Cerebral
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Síndrome Coronariana Aguda
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Tromboembolia Venosa
Tipo de estudo:
Estudo diagnóstico
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Estudo de etiologia
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo