In vitro Quality Evaluation of Apheresis Platelets in Four Kinds of Platelet Additive Solutions / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 55-67, 2016.
Article
em Ko
| WPRIM
| ID: wpr-22645
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Platelets (PLTs) stored in platelet additive solution (PAS) presents potential benefits in clinical use by reducing the risk of several plasma-associated adverse transfusion reactions and more plasma may be recovered for fractionation. In this study, we compared in vitro characteristics of apheresis PLTs stored in CompoSol PS (Fenwal, Lake Zurich, IL, USA), InterSol (Fenwal, Lake Zurich, IL, USA), SSP+ (MacoPharma, Tourcoing, France), T-PAS+ (Terumo BCT, Lakewood, CO, USA), or plasma to evaluate the effectiveness of PAS. METHODS: PLTs were collected two times by apheresis from 12 healthy volunteers in a study comparing four kinds of PASs with 35% autologous plasma and 100% plasma-stored apheresis PLTs. The parameters of PLTs, including PLT counts, pH, PLT activation markers, blood gases, and metabolic variables were assessed up to 7-day. RESULTS: The results of in vitro assay including PLT concentration, mean PLT volume, pH, and blood gases for PLTs in four kinds of PASs were similar to those in 100% plasma PLTs. All units had Day 5 pH greater than 6.2. In vitro quality rating results, PLTs in T-PAS+ had a rating of 5, 4 for CompoSol PS, 2 for SSP+, 1 for InterSol, and 2 for plasma on Day 5. CONCLUSION: Partial replacement of plasma with CompoSol PS, SSP+, or T-PAS+ in PLTs showed better or equivalent quality and preservability of PLTs compared to PLTs in 100% plasma. The use of PAS for storage of PLTs in clinical practice may have an advantage as PAS-stored PLTs have a reduced volume of plasma.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Plasma
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Remoção de Componentes Sanguíneos
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Incompatibilidade de Grupos Sanguíneos
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Plaquetas
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Lagos
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Voluntários Saudáveis
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Gases
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Concentração de Íons de Hidrogênio
Idioma:
Ko
Revista:
Korean Journal of Blood Transfusion
Ano de publicação:
2016
Tipo de documento:
Article