Antioxidant activities of licorice-derived prenylflavonoids
Nutrition Research and Practice
; : 491-498, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-227498
Biblioteca responsável:
WPRO
ABSTRACT
Glycyrrhiza uralensis (or licorice) is a widely used Oriental herbal medicine from which the phenylflavonoids dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. The purpose of the present study was to evaluate the antioxidant properties of DGC, DGD, and IsoA. The three compounds showed strong ferric reducing activities and effectively scavenged DPPH, ABTS+, and singlet oxygen radicals. Among the three compounds tested, DGC showed the highest free radical scavenging capacity in human hepatoma HepG2 cells as assessed by oxidant-sensitive fluorescent dyes dichlorofluorescein diacetate and dihydroethidium bromide. In addition, all three compounds effectively suppressed lipid peroxidation in rat tissues as well as H2O2-induced ROS production in hepatoma cells. This study demonstrates that among the three phenylflavonoids isolated from licorice, DGC possesses the most potent antioxidant activity, suggesting it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Digestório
/
Neoplasia Hepática
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Benzopiranos
/
Flavonoides
/
Peroxidação de Lipídeos
/
Doença Crônica
/
Espécies Reativas de Oxigênio
/
Carcinoma Hepatocelular
/
Glycyrrhiza uralensis
/
Oxigênio Singlete
/
Medicina Herbária
/
Etídio
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Nutrition Research and Practice
Ano de publicação:
2012
Tipo de documento:
Artigo