Pathogenesis of Sudden Manhood Death Syndrome / 대한법의학회지
Korean Journal of Legal Medicine
; : 19-26, 2009.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-227723
Biblioteca responsável:
WPRO
ABSTRACT
Sudden manhood death syndrome (SMDS) is a disorder found in southeast Asia, particularly Thailand, Philippines and Japan, which causes sudden cardiac death during sleep. In Korea, SMDS cases have been occasionally encountered in forensic autopsy practice. However, the incidence and pathogenesis has been rarely studied. This study to review chronologically the proposed pathogenesis of SMDS; pathology of cardiac conduction system, sleeping and breathing disorder, K+ and thiamine deficiency, mental stress, testosterone, hyperlipidemia, and narrow circumference of coronary artery. Brugada syndrome and SMDS are phenotypically, genetically and functionally the same disorder and Brugada syndrome has been a subject of intensive study since its early description in 1992. While Brugada syndrome is an inherited cardiac disorder caused by mutations in the SCN5A gene encoding the cardiac sodium channel alpha-subunit. less than 20% of its patients are known to be associated with SCN5A mutations. Moreover, the postmortem molecular screening of SCN5A mutations on formalin fixed paraffin embbeded cardiac tissues from SMDS cases has not been rewarding due to technical problems. The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in SMDS and Brugada syndrome is still debatable.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
/
Doença Cardiovascular
/
Doenças do Sistema Endócrino
/
Desnutrição e Deficiências Nutricionais
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parafina
/
Filipinas
/
Sudeste Asiático
/
Respiração
/
Recompensa
/
Autopsia
/
Testosterona
/
Tailândia
/
Deficiência de Tiamina
/
Canais de Sódio
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Legal Medicine
Ano de publicação:
2009
Tipo de documento:
Artigo