Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 78-84, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-229233
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. MATERIALS ANDMETHODS:
Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17.RESULTS:
CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P<0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P<0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P<0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P<0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P<0.05).CONCLUSION:
The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tiazinas
/
Biomarcadores
/
Cisto Dentígero
/
Cistos Odontogênicos
/
Diagnóstico Diferencial
/
Iminas
/
Queratinas
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2012
Tipo de documento:
Artigo