Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 70-72, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-229817
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.</p><p><b>METHODS</b>MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.</p><p><b>RESULTS</b>There was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).</p><p><b>CONCLUSION</b>The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Complicações na Gravidez
/
Estudos de Casos e Controles
/
Colestase Intra-Hepática
/
Citocromo P-450 CYP1A1
/
Predisposição Genética para Doença
/
Frequência do Gene
/
Genética
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Artigo