Study on the association of -689C/T polymorphism in the PPARgamma2 promoter with myocardial infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 19-22, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-229829
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of -689C/T polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) promoter with myocardial infarction (MI).</p><p><b>METHODS</b>This is a case-control study, which included 194 subjects with MI and 693 subjects without MI in nondiabetic Han population in Wuhan. Polymerase chain reaction-restriction fragment length polymorphism was used to determine the -689C-->T substitution.</p><p><b>RESULTS</b>The CC,CT, and TT genotype frequencies of -689C/T polymorphism were 88.1%,11.9%,and 0.0 in MI patients and 93.1%,6.6%,and 0.3% in controls, respectively (CC vs. CT+TT, P=0.025). The -689T allele was an independent risk factor for MI (OR=2.125, 95%CI 1.206-3.744, P=0.009) after adjusting for age,sex,waist circumference,body mass index, smoking, alcohol drinking, physical activities, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, level. The -689T allele carriers had significantly higher TC levels than noncarriers [(5.05+/-1.16) mmol/L vs. (4.78+/-1.05) mmol/L, P=0.004] in the total population.</p><p><b>CONCLUSION</b>The PPARgamma2 promoter -689C/T polymorphism is associated with an increased risk of MI.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
Modelos Logísticos
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Fatores de Risco
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Regiões Promotoras Genéticas
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Polimorfismo de Nucleotídeo Único
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PPAR gama
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Alelos
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Genética
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Genótipo
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Infarto do Miocárdio
Tipo de estudo:
Estudo de etiologia
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Adulto
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Idoso
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Artigo