Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in ethnic minority from Guizhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 589-591, 2007.
Article
em Zh
| WPRIM
| ID: wpr-229863
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in Dong, Yi and Yao ethnic groups from Guizhou.</p><p><b>METHODS</b>In 321 volunteers who were population-based, GSTM1 and GSTT1 polymorphisms were analyzed by a multiplex-PCR procedure, whereas GSTP1 polymorphism was analyzed by PCR-RFLP method.</p><p><b>RESULTS</b>Null genotype for GSTM1 and GSTT1 was 59.6%-71.2% and 39.4%-72.5%, respectively. The genotypic distribution of GSTP1 was 63.3%-75% for AA, 23.2%-35.8% for AG, 0-1.9% for GG, whereas the allelic frequencies were 81.2%-86.6% for the A allele, and 13.4%-18.8% for the G allele.</p><p><b>CONCLUSION</b>There is a significant relationship between GSTT1 frequencies and ethnic populations.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
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Etnicidade
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China
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Povo Asiático
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Glutationa S-Transferase pi
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Etnologia
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Frequência do Gene
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Genética
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Genótipo
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Glutationa Transferase
Limite:
Aged
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Aged80
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2007
Tipo de documento:
Article