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Relaxant effect of ethanol on isolated rabbit corpus cavernosum and its mechanism / 中华男科学杂志
National Journal of Andrology ; (12): 910-914, 2007.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-232040
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relaxant effect of ethanol on the isolated rabbit corpus cavernosum and its possible mechanism.</p><p><b>METHODS</b>The tension of isolated smooth muscle strips was recorded by the platform physiological graphed, and the concentrations of cAMP and cGMP in the rabbit corpus cavernosum were measured by 125I radioimmunoassay.</p><p><b>RESULTS</b>The 1.25% (V/V) ethanol significantly augmented the corporal relaxation induced by isoprenaline (10(-9) - 10(-5) mol/L). Ethanol-induced relaxation was inhibited by 100 micromol/L and 300 micromol/L SQ22536 (an adenylate cyclase inhibitor). Emax was depressed from (105.12 +/- 3.39) % to (97.00 +/- 2.57) % in the presence of 100 micromol/L SQ22536 or (91.09 +/- 2.42) % in the presence of 300 micromol/L SQ22536. EC50 was increased from (1.18 +/- 0.09)% (V/V) to (1.36 +/- 0.10) % in the presence of 100 micromol/L SQ22536 (P < 0.05) or (1.68 +/- 0.13) % (in the presence of 300 micromol/L SQ22536) (P < 0.05) respectively. Ethanol significantly elevated the level of cAMP but not that of cGMP in the isolated rabbit corpus cavernosum, and it also significantly enhanced the activity of the adenylate cyclase (AC) extracted from the rabbit corpus cavernosum in a dose-dependent manner.</p><p><b>CONCLUSION</b>Ethanol has a relaxant effect on the isolated rabbit corpus cavernosum, which may be associated with the cAMP signaling pathway.</p>
Assuntos
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Pênis / Farmacologia / Fisiologia / Técnicas In Vitro / Ereção Peniana / Transdução de Sinais / Depressores do Sistema Nervoso Central / AMP Cíclico / Etanol / Metabolismo Limite: Animais Idioma: Chinês Revista: National Journal of Andrology Ano de publicação: 2007 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Pênis / Farmacologia / Fisiologia / Técnicas In Vitro / Ereção Peniana / Transdução de Sinais / Depressores do Sistema Nervoso Central / AMP Cíclico / Etanol / Metabolismo Limite: Animais Idioma: Chinês Revista: National Journal of Andrology Ano de publicação: 2007 Tipo de documento: Artigo
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