Clinical features and therapeutic response of aplastic anemia patients with or without cytogenetic abnormalities / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 84-86, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-232199
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare clinical features and therapeutic response of patients with aplastic anemia with and without cytogenetic abnormalities.</p><p><b>METHODS</b>Clinical features of 133 patients with successful chromosomal analysis were retrospectively studied, and therapeutic response between patients with and without cytogenetic abnormalities was compared.</p><p><b>RESULTS</b>Cytogenetic abnormalities were found in 9 patients, which included trisomy 8 (4 cases), monosomy 7 (2 cases) and Xq- (1 case), 1q- (1 case) and 7q- (1 case). No significant difference was detected between patients with or without cytogenetic abnormalities in terms of age (50 vs. 58, P=0.337), sex ratio (male 55.56% vs. 62.10%, female 44.44% vs. 37.90%, P=0.762), or episode of acute aplastic anemia (44.44% vs. 37.10%, P=0.728). Patients with cytogenetic abnormalities had a tendency towards poorer rate of therapeutic response, which was however not significantly different from those without (55.56% vs. 79.03%, P=0.116). All of the 4 patients with +8 responded to treatment, whilst none of those with -7 or 7q- did.</p><p><b>CONCLUSION</b>No significant difference was found between aplastic anemia patients with or without cytogenetic abnormalities in terms of clinical features and therapeutic response. Patients with trisomy 8 seem to have a favorable response towards treatment.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Estudos Retrospectivos
/
Aberrações Cromossômicas
/
Resultado do Tratamento
/
Genética
/
Anemia Aplástica
/
Cariotipagem
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2013
Tipo de documento:
Artigo