Association study of NOS1 gene polymorphisms and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 459-463, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-232275
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.</p><p><b>METHODS</b>Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.</p><p><b>RESULTS</b>One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.</p><p><b>CONCLUSION</b>Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
Haplótipos
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Óxido Nítrico Sintase Tipo I
/
Genética
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2012
Tipo de documento:
Artigo