Advances in the chemical and biological studies of polyamides / 药学学报
Acta Pharmaceutica Sinica
; (12): 1089-1093, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-232638
Biblioteca responsável:
WPRO
ABSTRACT
Polyamides, containing N-methylpyrrole (Py) and N-methyl-imidazole (Im) amino acids, are synthetic oligomers programmed to read the DNA double helix in the minor groove with high affinities and sequence specificities resulting in modulation of gene expression. They are cell permeable, stable and have no cytotoxicity, which provide a promising tool of gene regulation. We describe here recent advances in the field of DNA binding polyamides, including pairing rules, specifities and affinities to DNA, synthesis methods, cellular and nuclear uptake properties, gene regulation and effectiveness in vivo. The potential problems and difficulties in future research are also discussed.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Pirróis
/
DNA
/
Química
/
Regulação da Expressão Gênica
/
Pegada de DNA
/
Pareamento de Bases
/
Genética
/
Imidazóis
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2008
Tipo de documento:
Artigo