Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation / 南方医科大学学报
Journal of Southern Medical University
; (12): 1449-1451, 2006.
Article
em Zh
| WPRIM
| ID: wpr-232863
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation.</p><p><b>METHODS</b>A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.</p><p><b>RESULTS</b>Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.</p><p><b>CONCLUSIONS</b>Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Cirurgia Geral
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Células da Medula Óssea
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Tetracloreto de Carbono
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Distribuição Aleatória
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Resultado do Tratamento
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Ratos Sprague-Dawley
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Transplante de Células-Tronco Hematopoéticas
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Biologia Celular
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Toxicidade
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Article