Molecular basis of partial D phenotypes in Chinese / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 587-591, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-233540
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the molecular basis of partial D phenotypes in Chinese, D variants with weak D expression was screened by using indirect anti-human globulin test (IAT) method, the polymerase chain reaction-sequence specific primer (PCR-SSP) method was employed to amplify RHD specific exons and their flanking regions. The amplification products were sequenced directly to determine the molecular basis of D variants. The results showed that ten cases of partial D phenotypes, including one case of D Va (Kou.), one case of D Va (Hus.), one case of D Va-like (YH.), and seven cases of D VI type III, were detected from 22 cases of weak D phenotype respectively. All ten cases of partial D phenotypes had one RHD allele deleted. In conclusion, the molecular basis of ten cases of partial D phenotype was confirmed, including D Va (Kou.) and D Va-like (YH.) phenotypes reported firstly in Chinese population.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Sistema do Grupo Sanguíneo Rh-Hr
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Povo Asiático
/
Alelos
/
Alergia e Imunologia
/
Genética
/
Mutação
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo