A prospective cohort study on human immunodeficiency virus and syphilis seroconversion among injecting drug users / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 293-297, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-233966
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the rate of human immunodeficiency virus (HIV) seroconversion, HIV transmission and related risk factors among injecting drug users (IDUs) in an area of Sichuan province.</p><p><b>METHODS</b>In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang county of Sichuan province, China. Follow-up visits were carried out every 6 months to study the situation of drug use, sexual behaviors of the IDUs and blood specimens were collected to test for antibodies against HIV and syphilis.</p><p><b>RESULTS</b>During a 24-month follow-up period, cohort retention rate and HIV incidence were 75.7% and 2.53 per 100 person-years [95% confidence interval (CI) 1.10-3.97)], respectively. Multivariate Poisson regression model showed that risk factors which were significantly associated with HIV seroconversion would include ethnicity (RR = 12.42; 95% CI 2.72-56.74, P = 0.0012) and needle or syringe sharing in the past 3 months (RR = 4.06; 95% CI 1.29-12.81, P = 0.0168). Syphilis seroconversion in this cohort was 4.71 per 100 person-years (95% CI 2.59-6.82). In multivariate Poisson regression being female (RR = 4.42; 95% CI 1.78-10.99, P = 0.0014) appeared to be the only factor which was significantly associated with syphilis seroconversion.</p><p><b>CONCLUSION</b>Our study results showed that there was a rapid transmission of HIV and syphilis among IDUs in Sichuan province, suggesting that effective intervention should be urgently taken.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Comportamento Sexual
/
Sífilis
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Abuso de Substâncias por Via Intravenosa
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Estudos Prospectivos
/
Fatores de Risco
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Estudos de Coortes
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Soropositividade para HIV
/
Alergia e Imunologia
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
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Estudo observacional
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Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2006
Tipo de documento:
Artigo